Research Interests & Foci
Jan 12, 2021
Sandy Brassel and Kristina Meriel have joined the lab as undergraduate research students. Welcome!
SEPT 01, 2020
Joshua Rychlik and Katy Sandoval have started their graduate studies as the inaugural members of the Choe lab!
The brain controls behaviour in an extremely complex manner, involving various processes at molecular, cellular, circuit, and network levels. Disease-linked gene mutations can create functional disruptions at any of these levels. In our lab, we use a multi-level, integrative research strategy to link how gene mutations associated with psychiatric disorders disrupt social behaviour.
OXYTOCIN AND ASD
Oxytocin is a peptide hormone known to influence key components of social behaviour, such as relationship bonding and trust. We are currently investigating potential molecular and circuit mechanisms involved in impaired function of the central oxytocin system and its link to the social symptoms of ASD.
CONVERGENT AND DIVERGENT MECHANISMS IN NEUROPSYCHIATRIC DISORDERS
Neuropsychiatric disorders such as autism spectrum disorders and schizophrenia have a significant genetic component. More than 100 risk genes have been identified for each condition, and a number of these overlap across disorders. On which neurobiological pathways do these gene mutations converge? Conversely, how do single gene disruptions serve as a risk factor for multiple psychiatric disorders? We aim to answer these questions using an integrative research pipeline that combines molecular, cellular, and circuit approaches in animal models.
Bulk and single-cell RNA-seq
Brain clearing (e.g. iDISCO)
In vitro slice electrophysiology
(extracellular, whole-cell patch-clamp)
In vivo multi-unit electrophysiology in freely behaving mice
3-chamber social interaction test
Juvenile social play
Open field test
MOUSE MAGNETIC RESONANCE IMAGING (MRI)
Katrina Choe, Ph.D.
Department of Psychology, Neuroscience & Behaviour (PNB)
B.Sc. (Hons.), University of Toronto
Ph.D. Neuroscience, McGill University
Postdoctoral Fellowship, UCLA
Fun Fact: Katrina loves to snowboard. Her favourite spots include Le Massif, Quebec and Cardrona, New Zealand!
Katy Celina Sandoval, M.Sc.
Neuroscience Graduate Program
M.Sc. Psychology, University of Calgary
B.Sc. Bishop's University
Fun Fact: Katy loves to sing Latin music. She has previously released two albums as a singer!
Undergraduate Research Student
Honours Program in Biology and Psychology, Neuroscience & Behaviour (PNB)
Fun Fact: Sandy's favourite colour is cerulean blue.
Undergraduate Research Student
Psychology, Neuroscience & Behaviour (PNB) Program
Fun Fact: Kristina has recently taken up a new hobby of building computers!
OPTOGENETIC FMRI AND ELECTROPHYSIOLOGICAL IDENTIFICATION OF REGION-SPECIFIC CONNECTIVITY BETWEEN THE CEREBELLAR CORTEX AND FOREBRAIN.
Choe, K.Y., Sanchez, C.F., Harris, N.G., Otis, T.S., and Mathews, P.J.
EFFECTS OF SALT LOADING ON THE MORPHOLOGY OF ASTROCYTES IN THE VENTRAL GLIA LIMITANS OF THE RAT SUPRAOPTIC NUCLEUS.
J Neuroendocrinology (2016)
Choe, K.Y., Prager-Khoutorsky, M., Farmer, W.T., Murai, K.K., and Bourque C.W.
HIGH SALT INTAKE INCREASES BLOOD PRESSURE VIA BDNF-MEDIATED DOWNREGULATION OF KCC2 AND IMPAIRED BAROREFLEX INHIBITION OF VASOPRESSIN NEURONS.
Choe, K.Y., Han, S.Y., Gaub, P., Shell, B., Voisin, D.L., Knapp, B.A., Barker, P.A., Brown, C., Cunningham,J.T., and Bourque, C.W.
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